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In Greece, people with rheumatic diseases amount to approximately 3.000.000 people. In the entire adult Greek population, 13% suffer from OA and 2% from inflammatory rheumatic diseases. The existing treatments do not always adequately cover the basic needs of these patients such as Satisfactory analgesic effect and reduction of inflammation and stiffness. In the adult population, the use of NSAIDs is widespread and in fact 70% of people over the age of 65 use NSAIDs at least once a week. However, the use of NSAIDs carries a significant risk of serious gastrointestinal, cardiovascular and renal side effects.
Libytec pharmaceutical has developed the PEAFORCE an innovative combination designed specifically to effectively and safely meet the needs of patients with pain such as musculoskeletal conditions, OA, PA etc.
The combination of its contained ingredients is unique and can offer strong analgesic, neuroprotective, chondroprotective and anti-inflammatory action and action on the endocannabinoid system. PEAFORCE contains:
Palmitoylethanolamide (PEA) is an endogenous lipid mediator that acts on the endocannabinoid system by directly or indirectly targeting different metabolic pathways. Administration of PEA may be beneficial in pain and inflammation
It has been shown to have neuroprotective, anti-inflammatory, and analgesic properties. Often in people with chronic disorders, the body does not produce enough PEA, which creates problems
A great advantage of PEA is that it is a safe, non-addictive substance that does not cover the pain, but aims to remove the cause. PEA can be taken by anyone suffering from painful disorders, even if they are taking medication, to enhance the effectiveness of the medications being taken.
Curcumin is a molecule that has been shown to have anti-inflammatory, antioxidant, healing and antimicrobial effects. Unlike synthetic drugs, it acts on multiple inflammatory metabolic pathways to help the body return to a normal balance. In addition, curcumin has specialized and unique mechanisms of action that make it invaluable in the treatment of painful conditions. Curcumin has been found to:
The result is that cartilage degradation is slowed down and curcumin has a positive effect on the degenerative inflammatory process in the joints, seen in rheumatoid arthritis and osteoarthritis
Piperine when combined with curcumin increases its bioavailability by 2.000%
Boswellic acids (BAAs) are active in various diseases such as osteoarthritis and rheumatoid arthritis. The most commonly used treatments for osteoarthritis include NSAIDs and pain relievers. Although these are an effective intervention, they do not affect the 5-LOX metabolic pathway
Suppression of 5-LOX synthesis by boswellic acids is considered to be the main mechanism for their anti-inflammatory action. The pharmacological action of AKBA includes:
B vitamins are a class of water-soluble vitamins that play an important role in cell metabolism. They are important for maintaining normal neurological functions. Deficiency in B vitamins can cause pain and inflammation.
Magnesium plays an essential role in energy regulation and the functioning of the nervous and muscular system. Low magnesium intake is associated with worsening pain and function and is considered an important risk factor for the development and progression of osteoarthritis
L-cysteine is a major source of various antioxidants such as glutathione (GSH), glutathione peroxidase, N-acetylcysteine (NAC) and α-lipoic acid
Therefore, PEAFORCE is an innovative unique combination that can offer effective and safe coverage of the needs of patients with painful disorders by adequately covering their basic needs such as:
